2'-Deoxy-2'-fluoroadenosine 5'-triphosphate (tetralithium)

2'-Deoxy-2'-fluoroadenosine 5'-triphosphate (tetralithium)

• UNSPSC Description: 2'-Deoxy-2'-fluoroadenosine 5'-triphosphate tetralithium is an ATP analog, it exerted a strong but mixed-type inhibition on poly(AU) synthesis.
• Target Antigen: DNA/RNA Synthesis
• Type: Oligonucleotides
• Related Pathways: Cell Cycle/DNA Damage
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/2-deoxy-2-fluoroadenosine-5-triphosphate-tetralithium.html
• Solubility: 10 mM in DMSO
• Smiles: F[C@@H]([C@@H]1N2C3=C(C(N)=NC=N3)N=C2)[C@H](O)[C@H](O1)COP(OP(OP(O[Li])(O[Li])=O)(O[Li])=O)(O[Li])=O
• Molecular Weight: 532.90
• References & Citations: [1]Kasuya T, et, al. Highly accurate synthesis of the fully 2'-fluoro-modified oligonucleotide by Therminator DNA polymerases. Bioorg Med Chem Lett. 2014 May 1; 24(9): 2134-6.|[2]Ishihama A, Enami M, Nishijima Y, Fukui T, Ohtsuka E, Ikehara M. 2'-Deoxy-2'-azidoadenosine triphosphate and 2'-deoxy-2'-fluoroadenosine triphosphate as substrates and inhibitors for Escherichia coli DNA-dependent RNA polymerase. J Biochem. 1980;87(3):825-830.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported