Products for Research Use Only
RegisterLogin

NSC-87877

CAT: 0804-HY-18756-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-18756-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26) [2].
CAS Number
56990-57-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Phosphatase; SHP1; SHP2
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/nsc-87877.html
Purity
99.0
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=S(C1=C2C=CC=NC2=C(O)C(/N=N/C3=CC=C4C=C(S(=O)(O)=O)C=CC4=C3)=C1)(O)=O
Molecular Formula
C19H13N3O7S2
Molecular Weight
459.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Chen L, et al. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol. 2006 Aug;70 (2) :562-70.|[2]Song M, et al. NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26) . Biochem Biophys Res Commun. 2009 Apr 17;381 (4) :491-5.|[3]Y Shi, et al. NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis. 2015 Aug 6;6 (8) :e1841.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Nsc-87877

8-oxo-7-[(6-sulfo-2-naphthalenyl)hydrazinylidene]-5-quinolinesulfonic acid is a naphthalenesulfonic acid.

CAS Number56990-57-9
PubChem CID92577
IUPAC Name8-hydroxy-7-[(6-sulfonaphthalen-2-yl)diazenyl]quinoline-5-sulfonic acid
Molecular FormulaC19H13N3O7S2
Molecular Weight459.5
XLogP2.4
Topological Polar Surface Area183
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count4
Heavy Atom Count31
Formal Charge0
Complexity883
SMILES
C1=CC2=C(C=C(C(=C2N=C1)O)N=NC3=CC4=C(C=C3)C=C(C=C4)S(=O)(=O)O)S(=O)(=O)O
InChI
InChI=1S/C19H13N3O7S2/c23-19-16(10-17(31(27,28)29)15-2-1-7-20-18(15)19)22-21-13-5-3-12-9-14(30(24,25)26)6-4-11(12)8-13/h1-10,23H,(H,24,25,26)(H,27,28,29)
InChIKey
XGMFVZOKHBRUTL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Nsc-87877
CAS: 56990-57-9
CID: 92577
Formula: C19H13N3O7S2
MW: 459.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight459.5
XLogP32.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count4
Exact Mass459.01949211
Monoisotopic Mass459.01949211
Topological Polar Surface Area183 Ų
Heavy Atom Count31
Formal Charge0
Complexity883
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-22159-01NSC 409012
HY-152168-01NSC 295642
HY-103380-01NSC 625987
HY-147288-01NSC 694621
HY-108543-01NSC 95397
HY-180480NSC 104999
HY-175848NSC 850745
HY-171152NSC 357754
HY-105293NSC 727357
HY-165077-01NSC 245214

Alternative Products

CatalogName
A4544-50NSC 87877
GTR19174813-01NSC-87877
T6911-01NSC-87877 disodium
A15384-50NSC 87877 50mg
A15384-100NSC 87877 100mg
A15384-25NSC 87877 25mg
A15384-10NSC 87877 10mg
A15384-5NSC 87877 5mg
MBS8506140-01NSC 131463 (NSC 133723)

Popular Products