Indinavir

• Description :

  Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir is also a SARS-CoV 3CLpro inhibitor[1][2][3][4].

• Product Name Alternative :

  MK-639 (free base) ; L-735524 (free base)

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H320

• Target :

  Apoptosis; HIV; HIV Protease; MMP; SARS-CoV

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Apoptosis; Metabolic Enzyme/Protease

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Inflammation/Immunology; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/indinavir.html

• Concentration :

  10mM

• Purity :

  99.96

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  O=C([C@@H](C[C@H](O)CN(CCN(CC1=CN=CC=C1)C2)[C@@H]2C(NC(C)(C)C)=O)CC3=CC=CC=C3)N[C@H]4C(C=CC=C5)=C5C[C@H]4O

• Molecular Formula :

  C36H47N5O4

• Molecular Weight :

  613.79

• Precautions :

  H315, H319, H320

• References & Citations :

  [1]Chavan S, et al. The HIV protease inhibitor Indinavir inhibits cell-cycle progression in vitro in lymphocytes of HIV-infected and uninfected individuals. Blood. 2001 Jul 15;98 (2) :383-9.|[2]Esposito V, et al. Evaluation of antitumoral properties of the protease inhibitor indinavir in a murine model of hepatocarcinoma. Clin Cancer Res. 2006 Apr 15;12 (8) :2634-9.|[3]Liu F, et al. Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S. J Mol Biol. 2005 Dec 9;354 (4) :789-800. |[4]Hall DC Jr, et al. A search for medications to treat COVID-19 via in silico molecular docking models of the SARS-CoV-2 spike glycoprotein and 3CL protease. Travel Med Infect Dis. 2020 May-Jun;35:101646.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  HIV-1; MMP-2

• Citation 01 :

  Antimicrob Agents Chemother. 2020 Aug 20;64 (9) :e00872-20.|Antiviral Res. 2022 Dec:208:105463.|Nat Commun. 2020 Sep 4;11 (1) :4417.|Toxicol In Vitro. 2023 Dec:93:105689.|bioRxiv. 2020 Apr.|Front Pharmacol. 2021 Apr 12;12:634097.|Int J Antimicrob Agents. 2019 Dec;54 (6) :814-819.|Signal Transduct Target Ther. 2021 May 29;6 (1) :212.

• CAS Number :

  [150378-17-9]