Indinavir (sulfate)

Indinavir (sulfate)

• CAS Number: 157810-81-6
• UNSPSC Description: Indinavir sulfate (MK-639) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir sulfate exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir sulfate is also a SARS-CoV 3CLpro inhibitor[1][2][3][4].
• Target Antigen: Apoptosis; HIV; HIV Protease; MMP; SARS-CoV
• Type: Reference compound
• Related Pathways: Anti-infection;Apoptosis;Metabolic Enzyme/Protease
• Applications: COVID-19-anti-virus
• Field of Research: Infection; Cancer
• Assay Protocol: https://www.medchemexpress.com/indinavir-sulfate.html
• Purity: 99.97
• Solubility: DMSO : ≥ 100 mg/mL|H2O : 50 mg/mL (ultrasonic)
• Smiles: O=C([C@@H](C[C@H](O)CN(CCN(CC1=CN=CC=C1)C2)[C@@H]2C(NC(C)(C)C)=O)CC3=CC=CC=C3)N[C@H]4C(C=CC=C5)=C5C[C@H]4O.O=S(O)(O)=O
• Molecular Weight: 711.87
• References & Citations: [1]Chavan S, et al. The HIV protease inhibitor Indinavir inhibits cell-cycle progression in vitro in lymphocytes of HIV-infected and uninfected individuals. Blood. 2001 Jul 15;98(2):383-9.|[2]Esposito V, et al. Evaluation of antitumoral properties of the protease inhibitor indinavir in a murine model of hepatocarcinoma. Clin Cancer Res. 2006 Apr 15;12(8):2634-9. |[3]Liu F, et al. Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S. J Mol Biol. 2005 Dec 9;354(4):789-800.|[4]Hall DC Jr, et al. A search for medications to treat COVID-19 via in silico molecular docking models of the SARS-CoV-2 spike glycoprotein and 3CL protease. Travel Med Infect Dis. 2020 May-Jun;35:101646.bioRxiv. 2020 Apr.|Front Pharmacol. 2021 Apr 12;12:634097.|Int J Antimicrob Agents. 2019 Dec;54(6):814-819.|Signal Transduct Target Ther. 2021 May 29;6(1):212.|Antimicrob Agents Chemother. 2020 Aug 20;64(9):e00872-20.|Antiviral Res. 2022 Nov 10;105463.|Nat Commun. 2020 Sep 4;11(1):4417.|Toxicol In Vitro. 2023 Sep 1;105689.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
• Clinical Information: Launched