Indinavir-d6

CAT: 0804-HY-B0689SSize: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0689SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Indinavir-d6 is the deuterium labeled Indinavir. Indinavir (MK-639; L735524) is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability.
CAS Number
[185897-02-3]
Product Name Alternative
MK-639-d6 (free base) ; L-735524-d6 (free base)
UNSPSC
12352005
Target
HIV; HIV Protease; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Others
Field of Research
Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
CC(C)(C)NC([C@H](CN(CC1)C([2H])([2H])C2=C([2H])N=C([2H])C([2H])=C2[2H])N1C[C@@H](O)C[C@@H](CC3=CC=CC=C3)C(N[C@H]4C5=CC=CC=C5C[C@H]4O)=O)=O
Molecular Formula
C36H41D6N5O4
Molecular Weight
619.83
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Stein, D.S., et al., A 24-week open-label phase I/II evaluation of the HIV protease inhibitor MK-639 (indinavir) . AIDS, 1996. 10 (5) : p. 485-92.|[3]Liu, F., et al., Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S. J Mol Biol, 2005. 354 (4) : p. 789-800.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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