Indinavir-d6

• Description :

  Indinavir-d6 is the deuterium labeled Indinavir. Indinavir (MK-639; L735524) is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability.

• Product Name Alternative :

  MK-639-d6 (free base) ; L-735524-d6 (free base)

• UNSPSC :

  12352005

• Target :

  HIV; HIV Protease; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease; Others

• Field of Research :

  Inflammation/Immunology

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(C)(C)NC([C@H](CN(CC1)C([2H])([2H])C2=C([2H])N=C([2H])C([2H])=C2[2H])N1C[C@@H](O)C[C@@H](CC3=CC=CC=C3)C(N[C@H]4C5=CC=CC=C5C[C@H]4O)=O)=O

• Molecular Formula :

  C36H41D6N5O4

• Molecular Weight :

  619.83

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Stein, D.S., et al., A 24-week open-label phase I/II evaluation of the HIV protease inhibitor MK-639 (indinavir) . AIDS, 1996. 10 (5) : p. 485-92.|[3]Liu, F., et al., Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S. J Mol Biol, 2005. 354 (4) : p. 789-800.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [185897-02-3]