2-Iminobiotin (Highly Pure)

• Description:

  2-Iminobiotin (Highly Pure)_x000D_ Catalog number: B2014433_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 10 mg_x000D_ Molecular Weight or Concentration: 243.33 g /mol_x000D_ Supplied as: Powder_x000D_ Applications: molecular tool for various biochemical applications_x000D_ Storage: 2-8°C_x000D_ Keywords: Guanidinobiotin, Hexahydro-2-imino-1H-thieno[3,4-d]imidazole-4-pentanoic acid_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Zitta K, Peeters-Scholte C, Sommer L, Gruenewald M, Hummitzsch L, Parczany K, Steinfath M, Albrecht M. 2-Iminobiotin Superimposed on Hypothermia Protects Human Neuronal Cells from Hypoxia-Induced Cell Damage: An in Vitro Study Front Pharmacol. 2018 Jan 11;8:971._x000D_ 2: Biselele T, Bambi J, Betukumesu DM, Ndiyo Y, Tabu G, Kapinga J, Bola V, Makaya P, Tjabbes H, Vis P, Peeters-Scholte C. A Phase IIa Clinical Trial of 2-Iminobiotin for the Treatment of Birth Asphyxia in DR Congo, a Low-Income Country Paediatr Drugs. 2020 Feb;22(1):95-104._x000D_ 3: Sup SJ, Green BG, Grant SK. 2-Iminobiotin is an inhibitor of nitric oxide synthases Biochem Biophys Res Commun. 1994 Oct 28;204(2):962-8._x000D_ 4: Fudem-Goldin B, Orr GA. 2-Iminobiotin-containing reagent and affinity columns Methods Enzymol. 1990;184:167-73._x000D_ 5: Orr GA. The use of the 2-iminobiotin-avidin interaction for the selective retrieval of labeled plasma membrane components J Biol Chem. 1981 Jan 25;256(2):761-6._x000D_ 6: Nijboer CH, Groenendaal F, Kavelaars A, Hagberg HH, van Bel F, Heijnen CJ. Gender-specific neuroprotection by 2-iminobiotin after hypoxia-ischemia in the neonatal rat via a nitric oxide independent pathway J Cereb Blood Flow Metab. 2007 Feb;27(2):282-92._x000D_ 7: Zitta K, Peeters-Scholte C, Sommer L, Parczany K, Steinfath M, Albrecht M. Insights into the neuroprotective mechanisms of 2-iminobiotin employing an in-vitro model of hypoxic-ischemic cell injury Eur J Pharmacol. 2016 Dec 5;792:63-69._x000D_ 8: van den Tweel ER, van Bel F, Kavelaars A, Peeters-Scholte CM, Haumann J, Nijboer CH, Heijnen CJ, Groenendaal F. Long-term neuroprotection with 2-iminobiotin, an inhibitor of neuronal and inducible nitric oxide synthase, after cerebral hypoxia-ischemia in neonatal rats J Cereb Blood Flow Metab. 2005 Jan;25(1):67-74._x000D_ 9: van Hoogdalem EJ, Peeters-Scholte CMPCD, Leufkens PWTJ, Hartstra J, van Lier JJ, de Leede LGJ. First-in-Human Study of the Safety, Tolerability, Pharmacokinetics and - Preliminary Dynamics of Neuroprotectant 2-Iminobiotin in Healthy Subjects Curr Clin Pharmacol. 2020;15(2):152-163._x000D_ 10: Favi LMA, Peeters-Scholte CMPCD, Bakker A, Tjabbes H, Egberts TCG, van Bel F, Rademaker CMA, Vis P, Groenendaal F. Pharmacokinetics and short-term safety of the selective NOS inhibitor 2-iminobiotin in asphyxiated neonates treated with therapeutic hypothermia Pediatr Res. 2020 Mar;87(4):689-696. _x000D_ _x000D_ Products Related to 2-Iminobiotin (Highly Pure) can be found at Chemicals

• Short Description:

  Catalog Number: B2014433 (10 mg)

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height:

  0.5

• Height :

  0.5