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2-Iminobiotin

CAT: 0804-HY-118700-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-118700-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
2-Iminobiotin (Guanidinobiotin) is a biotin (vitamin H or B7) analog. 2-Iminobiotin is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5μM for murine iNOS and rat n-cNOS, respectively[1]. 2-Iminobiotin superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage[2].
CAS Number
13395-35-2
Product Name Alternative
Guanidinobiotin
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/2-iminobiotin.html
Purity
99.95
Solubility
DMSO : 9.09 mg/mL (ultrasonic; adjust pH to 6 with 1 M HCl)
Smiles
[H][C@](CS[C@H]1CCCCC(O)=O)([C@]1([H])N2)NC2=N
Molecular Formula
C10H17N3O2S
Molecular Weight
243.33
Precautions
H302, H312, H332
References & Citations
[1]Sup SJ, et al. 2-Iminobiotin is an inhibitor of nitric oxide synthases. Biochem Biophys Res Commun. 1994 Oct 28;204 (2) :962-8.|[2]Zitta K, et al. 2-Iminobiotin Superimposed on Hypothermia Protects Human Neuronal Cells from Hypoxia-Induced Cell Damage: An in Vitro Study. Front Pharmacol. 2018 Jan 11;8:971.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
INOS

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