Polyphyllin VI (Standard)

CAT: 0804-HY-N0816R-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-N0816R-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Polyphyllin VI (Standard) is the analytical standard of Polyphyllin VI. This product is intended for research and analytical applications. Polyphyllin VI, an active saponin, possess anti-cancer activities. Polyphyllin VI induces G2/M cell cycle arrest and triggers apoptosis. Polyphyllin VI induces caspase-1-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer[1][2][3].

CAS Number

55916-51-3

UNSPSC

12352005

Target

Apoptosis; Pyroptosis; Reference Standards

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Others

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/polyphyllin-vi-standard.html

Smiles

O[C@]1([C@@]2([H])O[C@]3(CC[C@@H](C)CO3)[C@H]1C)[C@]([C@@]4([H])C2)(CC[C@@]5([H])[C@@]4([H])CC=C6[C@@]5(CC[C@H](O[C@@](O[C@H](CO)[C@@H](O)[C@@H]7O)([H])[C@@H]7O[C@@](O[C@@H](C)[C@H](O)[C@H]8O)([H])[C@@H]8O)C6)C)C

Molecular Formula

C39H62O13

Molecular Weight

738.90

References & Citations

[1]Lin Z, et al. Anti-lung Cancer Effects of Polyphyllin VI and VII Potentially Correlate with Apoptosis In Vitro and In Vivo. Phytother Res. 2015 Oct;29 (10) :1568-76.|[2]Liu Y, et al. Molecular Mechanisms of Apoptosis in HepaRG Cell Line Induced by Polyphyllin VI via the Fas Death Pathway and Mitochondrial-Dependent Pathway. Toxins (Basel) . 2018 May 15;10 (5) . pii: E201.|[3]Jin-Feng Teng, et al. Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer. Cancers (Basel) . 2020 Jan 13;12 (1) :193.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Related Products

Catalog	Name
HY-N0816-01	Polyphyllin VI
HY-N0047R	Polyphyllin I (Standard)
HY-N0265R-01	Asperosaponin VI (Standard)
HY-N0047-01	Polyphyllin I
HY-W019830-01	Polyphyllin F
HY-N0817	Polyphyllin G
HY-N2382-01	Polyphyllin H
HY-W019829	Polyphyllin C
HY-N2386	Polyphyllin E
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294500-01	Polyphyllin A
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T3895-01	Polyphyllin I
AB1965	Polyphyllin VII
AB0596	Polyphyllin VI
MBS579647	Polyphyllin B
BUP08231-01	Polyphyllin H

Polyphyllin VI (Standard)

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