Polyphyllin I

CAT: 0931-T3895-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T3895-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
50773-41-6
Target
Akt|||Apoptosis|||mTOR|||Autophagy|||JNK|||PDK
Related Pathways
PI3K/Akt/mTOR signaling|||Autophagy|||Cytoskeletal Signaling|||MAPK|||Apoptosis
Purity
0.995
Bioactivity
Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D has an anti-angiogenic effect. Polyphyllin D has toxicity in human RBCs as well as its underlying mechanism for the hemolysis and eryptosis/erythroptosis. Polyphyllin D has strong anticancer activity, can overcome drug resistance in R-HepG2 cells and elicit programmed cell death via mitochondrial dysfunction.
Smiles
[H][C@]12C[C@@]3([H])[C@]4([H])CC=C5C[C@H](CC[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@@]1([H])[C@H](C)[C@@]1(CC[C@@H](C)CO1)O2)O[C@]1([H])O[C@H](CO)[C@@H](O[C@]2([H])O[C@@H](CO)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@]1([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O
Molecular Formula
C44H70O16
Molecular Weight
855.02
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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294500-01Polyphyllin A
TP049263Polyphyllin Ⅵ
TP049264Polyphyllin Ⅶ
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