Polyphyllin I

• Target :

  Akt|||Apoptosis|||mTOR|||Autophagy|||JNK|||PDK

• Related Pathways :

  PI3K/Akt/mTOR signaling|||Autophagy|||Cytoskeletal Signaling|||MAPK|||Apoptosis

• Purity :

  0.995

• Bioactivity :

  Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D has an anti-angiogenic effect. Polyphyllin D has toxicity in human RBCs as well as its underlying mechanism for the hemolysis and eryptosis/erythroptosis. Polyphyllin D has strong anticancer activity, can overcome drug resistance in R-HepG2 cells and elicit programmed cell death via mitochondrial dysfunction.

• Smiles :

  [H][C@]12C[C@@]3([H])[C@]4([H])CC=C5C[C@H](CC[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@@]1([H])[C@H](C)[C@@]1(CC[C@@H](C)CO1)O2)O[C@]1([H])O[C@H](CO)[C@@H](O[C@]2([H])O[C@@H](CO)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@]1([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O

• Molecular Formula :

  C44H70O16

• Molecular Weight :

  855.02

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  50773-41-6