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Polyphyllin G

CAT: 0804-HY-N0817Size: InquireDry Ice: NoHazardous: No
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CAT#:0804-HY-N0817Size:Inquire
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
76296-75-8
UNSPSC Description
Polyphyllin G is isolated from the rhizomes of Paris yunnanensis, with antimicrobial and anticancer activity. Polyphyllin G prevents the growth of both Gram-positive and Gram-negative bacteria with minimum inhibitory concentrations (MICs)[1]. Polyphyllin G induces apoptosis dependent on the activations of caspase-8, -3, and -9, induces autophagy[2].
Target Antigen
Apoptosis; Autophagy; Bacterial
Type
Natural Products
Related Pathways
Anti-infection;Apoptosis;Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/polyphyllin-g.html
Solubility
10 mM in DMSO
Smiles
C[C@H]1[C@H]2[C@@H](O[C@@]1(OC)CC[C@H](CO[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)C)C[C@@H]4[C@]2(C)CC[C@H]5[C@H]4CC=C6[C@]5(C)CC[C@H](O[C@@H]7[C@@H](O)[C@H](O[C@H]8[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O8)[C@@H](O[C@H]9[C@H](O)[C@@H](O)[C@H](CO)O9)[C@H](CO)O7)C6
Molecular Weight
1049.20
References & Citations
[1]Cai X, et al. Polyphyllin G exhibits antimicrobial activity and exerts anticancer effects on human oral cancer OECM-1 cells by triggering G2/M cell cycle arrest by inactivating cdc25C-cdc2. Arch Biochem Biophys. 2018 Apr 15;644:93-99.|[2]Hsieh MJ, et al. Polyphyllin G induces apoptosis and autophagy cell death in human oral cancer cells. Phytomedicine. 2016 Dec 1;23(13):1545-1554.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported

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