Polyphyllin C

• Description :

  Polyphyllin C (compound 2) is a spirostanol saponin. Polyphyllin C exhibits mild (IC50=36.87 µM) activities against the tyrosinase and moderate (IC50=1.59 µg/mL) antileishmanial activities[1][2].

• UNSPSC :

  12352005

• Target :

  Parasite; Tyrosinase

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/polyphyllin-c.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@@H]1CC[C@]2(OC1)[C@@H](C)[C@H]3[C@H](C[C@@H]4[C@]3(C)CC[C@H]5[C@H]4CC=C6[C@]5(C)CC[C@H](O[C@H]7[C@H](O)[C@@H](O[C@H]8[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O8)[C@H](O)[C@@H](CO)O7)C6)O2

• Molecular Formula :

  C39H62O12

• Molecular Weight :

  722.90

• References & Citations :

  [1]Devkota KP, et, al. Tyrosinase inhibitory and antileishmanial constituents from the rhizomes of Paris polyphylla. Nat Prod Res. 2007 Apr;21 (4) :321-7.|[2]Singh SB, et, al. Spirostanol saponins from Paris polyphylla, structures of polyphyllin C, D, E and F. Phytochemistry.1980; 21 (12) : 2925-2929.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Leishmania

• CAS Number :

  [76296-71-4]