Cletoquine (oxalate)
CAT:
804-HY-135810A-02
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Cletoquine (oxalate)
- CAS Number: 14142-64-4
- UNSPSC Description: Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine oxalate is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine oxalate is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine oxalate has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].
- Target Antigen: Influenza Virus; Parasite
- Type: Reference compound
- Related Pathways: Anti-infection
- Field of Research: Infection; Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/cletoquine-oxalate.html
- Smiles: CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCNCCO.O=C(O)C(O)=O
- Molecular Weight: 397.85
- References & Citations: [1]Kumar M, et al. Molecular docking studies of chloroquine and its derivatives against P23pro-zbd domain of chikungunya virus: Implication in designing of novel therapeutic strategies. J Cell Biochem. 2019 Oct;120(10):18298-18308.|[2]Charlier B, et al. Development of a novel ion-pairing HPLC-FL method for the separation and quantification of hydroxychloroquine and its metabolites in whole blood. Biomed Chromatogr. 2018 Aug;32(8):e4258.|[3]Chhonker YS, et al. Simultaneous quantitation of hydroxychloroquine and its metabolites in mouse blood and tissues using LC-ESI-MS/MS: An application for pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 1;1072:320-327.
- Shipping Conditions: Room Temperature