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Emedastine (difumarate)

CAT: 0804-HY-B2178Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B2178Size:1 Each
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Description
Emedastine difumarate is an orally active, selective and high affinity histamine H1 receptor antagonist with a Ki value of 1.3 nM. Emedastine difumarate is a benzimidazole derivative with potent antiallergic properties and used for allergic rhinitis, allergic skin diseases and allergic conjunctivitis[1][2][3].
CAS Number
87233-62-3
UNSPSC
12352005
Hazard Statement
H302
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/emedastine-difumarate.html
Solubility
10 mM in DMSO
Smiles
CN1CCN(C2=NC3=CC=CC=C3N2CCOCC)CCC1.O=C(O)/C=C/C(O)=O.O=C(O)/C=C/C(O)=O
Molecular Formula
C25H34N4O9
Molecular Weight
534.56
Precautions
P264-P270-P330-P501
References & Citations
[1]Sharif NA, et al. Emedastine: a potent, high affinity histamine H1-receptor-selective antagonist for ocular use: receptor binding and second messenger studies. J Ocul Pharmacol. 1994 Winter;10 (4) :653-64.|[2]Murota H, et al. Emedastine difumarate: a review of its potential ameliorating effect for tissue remodeling in allergic diseases. Expert Opin Pharmacother. 2009 Aug;10 (11) :1859-67.|[3]Andoh T, et al. Involvement of blockade of leukotriene B (4) action in anti-pruritic effects of emedastine in mice. Eur J Pharmacol. 2000 Oct 6;406 (1) :149-52.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
H1 Receptor; H2 Receptor; H3 Receptor

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