Emedastine

CAT: 0804-HY-108411-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-108411-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Emedastine is an orally active, selective and high affinity histamine H1 receptor antagonist with a Ki value of 1.3 nM. Emedastine is a benzimidazole derivative with potent antiallergic properties and used for allergic rhinitis, allergic skin diseases and allergic conjunctivitis[1][2][3].

CAS Number

87233-61-2

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/emedastine.html

Purity

98.01

Solubility

DMSO : 125 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic)

Smiles

CN1CCN(C2=NC3=CC=CC=C3N2CCOCC)CCC1

Molecular Formula

C17H26N4O

Molecular Weight

302.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Sharif NA, et al. Emedastine: a potent, high affinity histamine H1-receptor-selective antagonist for ocular use: receptor binding and second messenger studies. J Ocul Pharmacol. 1994 Winter;10 (4) :653-64.|[2]Murota H, et al. Emedastine difumarate: a review of its potential ameliorating effect for tissue remodeling in allergic diseases. Expert Opin Pharmacother. 2009 Aug;10 (11) :1859-67.|[3]Andoh T, et al. Involvement of blockade of leukotriene B (4) action in anti-pruritic effects of emedastine in mice. Eur J Pharmacol. 2000 Oct 6;406 (1) :149-52.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

H1 Receptor; H2 Receptor; H3 Receptor

Alternative Products

Catalog	Name
BA5404-10	Emedastine
TRC-E521520-250MG	Emedastine Difumerate
TRC-E521527-100MG	Emedastine-d3
MBS3842475-01	Emedastine Difumarate
A22158-100	Emedastine 100mg
A22158-50	Emedastine 50mg
A22158-5	Emedastine 5mg

Emedastine

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