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IMB-XH1

CAT: 0804-HY-12826-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12826-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IMB-XH1 is an inhibitor of myeloid cell factor 1 (Mcl-1) [1]. IMB-XH1 is a non-competitive Delhi metallo-β-lactamase (NDM-1) inhibitor. The IC50s of IMB-XH1 against metallo-β-lactamases NDM-1, IMP-4, ImiS and L1 are 0.4637 μM, 3.980 μM, 0.2287 μM and 1.158 μM, respectively[2].
CAS Number
292057-76-2
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Bacterial; Bcl-2 Family; Beta-lactamase
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Mcl1-IN-2.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
OC1=C(N=CC=C2)C2=CC=C1C(NC3=CC=CC=N3)C4=CC=CS4
Molecular Formula
C19H15N3OS
Molecular Weight
333.41
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Richard DJ, et al. Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker. Bioorg Med Chem. 2013 Nov 1;21 (21) :6642-9.|[2]Jiangxue Han, et al. IMB-XH1 identified as a novel inhibitor of New Delhi metallo-β-lactamase-1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Mcl-1

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