IMB-XH1

• Description :

  IMB-XH1 is an inhibitor of myeloid cell factor 1 (Mcl-1) [1]. IMB-XH1 is a non-competitive Delhi metallo-β-lactamase (NDM-1) inhibitor. The IC50s of IMB-XH1 against metallo-β-lactamases NDM-1, IMP-4, ImiS and L1 are 0.4637 μM, 3.980 μM, 0.2287 μM and 1.158 μM, respectively[2].

• CAS Number :

  [292057-76-2]

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Bacterial; Bcl-2 Family; Beta-lactamase

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Mcl1-IN-2.html

• Concentration :

  10mM

• Purity :

  98.0

• Solubility :

  DMSO : 33.33 mg/mL (ultrasonic)

• Smiles :

  OC1=C(N=CC=C2)C2=CC=C1C(NC3=CC=CC=N3)C4=CC=CS4

• Molecular Formula :

  C19H15N3OS

• Molecular Weight :

  333.41

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Richard DJ, et al. Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker. Bioorg Med Chem. 2013 Nov 1;21 (21) :6642-9.|[2]Jiangxue Han, et al. IMB-XH1 identified as a novel inhibitor of New Delhi metallo-β-lactamase-1.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Mcl-1