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EPZ-4777

CAT: 0804-HY-111589Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-111589Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EPZ-4777 is a selective DOT1L inhibitor which inhibits H3K79 methylation in cancer cells, blocks the expression of leukemogenic genes, and selectively kills cells that contain the translocation. EPZ-4777 can be used for cancer research[1].
CAS Number
1381761-52-9
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/epz-4777.html
Smiles
O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@H]3CN(CCCNC(NC4=CC=C(C(C)(C)C)C=C4)=O)C(C)C
Molecular Formula
C27H40N8O4
Molecular Weight
540.66
References & Citations
[1]Bon C, et al. Synthesis and Biological Activity of a Cytostatic Inhibitor of MLLr Leukemia Targeting the DOT1L Protein. Molecules. 2021 Aug 31;26 (17) :5300.|[2]Lillico R, et al. Selective DOT1L, LSD1, and HDAC Class I Inhibitors Reduce HOXA9 Expression in MLL-AF9 Rearranged Leukemia Cells, But Dysregulate the Expression of Many Histone-Modifying Enzymes. J Proteome Res. 2018 Aug 3;17 (8) :2657-2667.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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