RegisterLogin

UNC4976 (TFA)

CAT: 0804-HY-126327A-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-126327A-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
UNC4976 TFA is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids. UNC4976 TFA simultaneously antagonizes H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA[1].
UNSPSC
12352209
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/unc4976-tfa.html
Purity
98.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
COC([C@H](CO)NC([C@H](CCCCN(C)C1C2CCC(C2)C1)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CC3=CC=CC=C3)NC(C4=CC=C(C(C)(C)C)C=C4)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
Molecular Formula
C49H71F3N6O10
Molecular Weight
961.12
References & Citations
[1]Lamb KN, et al. Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7. Cell Chem Biol. 2019 Aug 14.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-126327UNC4976
HY-P3460A-01TDSRCVIGLYHPPLQVY (TFA)
HY-P5229A-01IHRIC (TFA)
HY-P1149A-01Epitalon (TFA)
HY-P0205B-01Saralasin (TFA)
HY-P3333A-01KSPWFTTL (TFA)
HY-P10582A-01SIYNFEKL (TFA)
HY-P1120AWKYMVm (TFA)
HY-D1690SBADA (TFA)
HY-P2093AS961 (TFA)

Alternative Products

CatalogName
T73903-01UNC4976 TFA
MBS5767813UNC4976
MBS3611039-01Dermorphin TFA
M40534-01Katacalcin TFA
M40541-01Tirzepatide TFA
M40587-01Chlorotoxin TFA
M40605-01Xenopsin TFA
M40612-01Tyroserleutide TFA
M40627-01CGGRGD TFA
M40631-01CysHHC10 TFA

Popular Products