UNC4976 (TFA)

• Description:

  UNC4976 TFA is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids. UNC4976 TFA simultaneously antagonizes H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA[1].

• UNSPSC:

  12352209

• Target:

  Histone Methyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/unc4976-tfa.html

• Purity:

  98.0

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  COC ([C@H] (CO) NC ([C@H] (CCCCN (C) C1C2CCC (C2) C1) NC ([C@H] (CC (C) C) NC ([C@H] (C) NC ([C@H] (CC3=CC=CC=C3) NC (C4=CC=C (C (C) (C) C) C=C4) =O) =O) =O) =O) =O) =O.OC (C (F) (F) F) =O

• Molecular Formula:

  C49H71F3N6O10

• Molecular Weight:

  961.12

• References & Citations:

  [1]Lamb KN, et al. Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7. Cell Chem Biol. 2019 Aug 14.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported