Nutlin-3
CAT:
804-HY-50696-03
Size:
5 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Nutlin-3
- CAS Number: 548472-68-0
- UNSPSC Description: Nutlin-3 is a commercial available p53-MDM2 inhibitor, with Ki of 90 nM.
- Target Antigen: E1/E2/E3 Enzyme; MDM-2/p53
- Type: Reference compound
- Related Pathways: Apoptosis;Metabolic Enzyme/Protease
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/Nutlin-3.html
- Purity: 98.90
- Solubility: DMSO : ≥ 50 mg/mL|Ethanol : 100 mg/mL (ultrasonic)
- Smiles: O=C1NCCN(C(N2[C@@H](C3=CC=C(Cl)C=C3)[C@@H](C4=CC=C(Cl)C=C4)N=C2C5=CC=C(OC)C=C5OC(C)C)=O)C1
- Molecular Weight: 581.49
- References & Citations: [1]Yu Z, et al. Design, synthesis and biological evaluation of sulfamide and triazole benzodiazepines as novel p53-MDM2 inhibitors. Int J Mol Sci. 2014 Sep 5;15(9):15741-53.|[2]Zhang Y, et al. Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth.Cancer Biol Ther. Cancer Biol Ther. 2012 Aug;13(10):915-24.|[3]Supiot S, et al. Nutlin-3 radiosensitizes hypoxic prostate cancer cells independent of p53. Mol Cancer Ther. 2008 Apr;7(4):993-9.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported