NPR-C activator 1

NPR-C activator 1

• CAS Number: 2768328-61-4
• UNSPSC Description: NPR-C activator 1 (Compound 1) is a potent activator of natriuretic peptide receptor C (NPR-C). C-type natriuretic peptide (CNP) is involved in the regulation of vascular homeostasis. NPR-C activator 1 is identified as a potent agonist (EC50 ∼ 1 μM) with promising in vivo pharmacokinetic properties[1].
• Target Antigen: Guanylate Cyclase; Others
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Others
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/npr-c-activator-1.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: CC(NC1=CC=C(C=C1)NC2=NC=NC(NCCC(OC(C)(C)C)=O)=N2)=O
• Molecular Weight: 372.42
• References & Citations: [1]Smith RJ, et al. A Series of Substituted Bis-Aminotriazines Are Activators of the Natriuretic Peptide Receptor C. J Med Chem. 2022 Apr 14;65(7):5495-5513.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported