NPR-C activator 1

• UNSPSC Description:

  NPR-C activator 1 (Compound 1) is a potent activator of natriuretic peptide receptor C (NPR-C). C-type natriuretic peptide (CNP) is involved in the regulation of vascular homeostasis. NPR-C activator 1 is identified as a potent agonist (EC50 ∼ 1 μM) with promising in vivo pharmacokinetic properties[1].

• Target Antigen:

  Guanylate Cyclase; Others

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Others

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/npr-c-activator-1.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CC(NC1=CC=C(C=C1)NC2=NC=NC(NCCC(OC(C)(C)C)=O)=N2)=O

• Molecular Weight:

  372.42

• References & Citations:

  [1]Smith RJ, et al. A Series of Substituted Bis-Aminotriazines Are Activators of the Natriuretic Peptide Receptor C. J Med Chem. 2022 Apr 14;65(7):5495-5513.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2768328-61-4