NPR-C activator 1

• Description:

  NPR-C activator 1 (Compound 1) is a potent activator of natriuretic peptide receptor C (NPR-C) . C-type natriuretic peptide (CNP) is involved in the regulation of vascular homeostasis. NPR-C activator 1 is identified as a potent agonist (EC50 ∼ 1 μM) with promising in vivo pharmacokinetic properties[1].

• UNSPSC:

  12352005

• Target:

  Guanylate Cyclase

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/npr-c-activator-1.html

• Purity:

  99.30

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CC(NC1=CC=C(C=C1)NC2=NC=NC(NCCC(OC(C)(C)C)=O)=N2)=O

• Molecular Formula:

  C18H24N6O3

• Molecular Weight:

  372.42

• References & Citations:

  [1]Smith RJ, et al. A Series of Substituted Bis-Aminotriazines Are Activators of the Natriuretic Peptide Receptor C. J Med Chem. 2022 Apr 14;65 (7) :5495-5513.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2768328-61-4]