WCK-4234

CAT: 0804-HY-125604-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-125604-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
WCK-4234 is a potent β-lactamase inhibitor. WCK-4234 inhibits class A, C, and D β-lactamases activity. WCK-4234 lacks direct antibacterial activity. WCK-4234 potentiates imipenem and meropenem against Enterobacteriaceae with OXA-48/OXA-181 or KPC enzymes, or with combinations of impermeability and AmpC or ESBL activity. WCK-4234 distinctively overcomes resistance mediated by OXA-type carbapenemases[1][2].
CAS Number
[1804915-68-1]
UNSPSC
12352005
Target
Bacterial; Beta-lactamase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/wck-4234.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(ON1[C@@H]2CC[C@@H](C#N)[N@@](C2)C1=O)(O[Na])=O
Molecular Formula
C7H8N3NaO5S
Molecular Weight
269.21
References & Citations
[1]Iregui A, et al. Activity of Meropenem with a Novel Broader-Spectrum β-Lactamase Inhibitor, WCK 4234, against Gram-Negative Pathogens Endemic to New York City. Antimicrob Agents Chemother. 2019 Dec 20;64 (1) :e01666-19.|[2]Mushtaq S, et al. WCK 4234, a novel diazabicyclooctane potentiating carbapenems against Enterobacteriaceae, Pseudomonas and Acinetobacter with class A, C and D β-lactamases. J Antimicrob Chemother. 2017 Jun 1;72 (6) :1688-1695.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-107075AWCK-1152
HY-120366WCK-5153
HY-106975SCH-42354
HY-13108-01Bz 423
HY-112142-01AB-423
HY-167900CMV-423
HY-W953305CRBN ligand-423
HY-112142A(Rac) -AB-423
HY-RI00926A-01Hsa-miR-423-5p antagomir
HY-R00926-01Hsa-miR-423-5p mimic

Alternative Products

CatalogName
BA1430-10WCK-4234
MBS3616338-01WCK-4234 sodium
555242WCK-5153
TL303283METTL1 Human shRNA Plasmid Kit (Locus ID 4234)
SR302874METTL1 Human siRNA Oligo Duplex (Locus ID 4234)
RI01426RI Std at 20C 1.4234 Solvent Based 15mL
TL303283VMETTL1 Human shRNA Lentiviral Particle (Locus ID 4234)

Popular Products