AZ12601011

CAT: 0804-HY-122856-01Size: 5 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-122856-01Size:5 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor with an IC50 of 18 nM and a Kd of 2.9 nM. AZ12601011 inhibits phosphorylation of SMAD2 via selectively inhibiting ALK4, TGFBR1, and ALK7. AZ12601011 inhibits mammary tumor growth [1].

CAS Number

2748337-86-0

UNSPSC

12352005

Target

TGF-β Receptor

Type

Reference compound

Related Pathways

TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/az12601011.html

Concentration

10mM

Purity

99.78

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

C1(C2=NC=CC=C2)=NC(N3C=CC4=C3C=CN=C4)=C(CCC5)C5=N1

Molecular Formula

C19H15N5

Molecular Weight

313.36

References & Citations

[1]Spender LC, et al. Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor βSuperfamily Type 1 Receptors. Mol Pharmacol. 2019 Feb;95 (2) :222-234.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ALK4; ALK7

Alternative Products

Catalog	Name
BA9159-5.1	AZ12601011
M32795-01	AZ12601011 B

AZ12601011

Alternative Products

Popular Products