PPACK (TFA)

CAT: 0804-HY-122542B-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-122542B-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PPACK TFA is potent, selective and irreversible thrombin inhibitor. PPACK TFA can be used an alternative anticoagulant to lithium heparin (LiHep) for blood gas and whole-blood electrolyte analyses. PPACK TFA is also a plasminogen activator (rt-PA) inhibitor. PPACK TFA can inhibit the binding of rt-PA to plasma protease inhibitors[1][2].
CAS Number
[157379-44-7]
UNSPSC
12352209
Target
PAI-1; Thrombin
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ppack-tfa.html
Concentration
10mM
Purity
99.80
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C([C@H]1N(CCC1)C([C@H](N)CC2=CC=CC=C2)=O)N[C@@H](CCCNC(N)=N)C(CCl)=O.O=C(C(F)(F)F)O
Molecular Formula
C23H32ClF3N6O5
Molecular Weight
564.99
References & Citations
[1]Mohler MA, et al. D-Phe-Pro-Arg-chloromethylketone: its potential use in inhibiting the formation of in vitro artifacts in blood collected during tissue-type plasminogen activator thrombolytic therapy. Thromb Haemost. 1986;56 (2) :160-164.|[2]Lyon ME, et, al. D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone (PPACK) : alternative anticoagulant to heparin salts for blood gas and electrolyte specimens. Clin Chem. 1995 Jul;41 (7) :1038-41.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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