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PPACK

CAT: 0804-HY-122542Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-122542Size:1 Each
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Description
PPACK is potent, selective and irreversible thrombin inhibitor. PPACK can be used an alternative anticoagulant to lithium heparin (LiHep) for blood gas and whole-blood electrolyte analyses. PPACK is also a plasminogen activator (rt-PA) inhibitor. PPACK can inhibit the binding of rt-PA to plasma protease inhibitors[1][2].
CAS Number
71142-71-7
UNSPSC
12352209
Target
PAI-1; Thrombin
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ppack.html
Solubility
10 mM in DMSO
Smiles
O=C(N1[C@@H](CCC1)C(N[C@@H](CCCNC(N)=N)C(CCl)=O)=O)[C@@H](CC2=CC=CC=C2)N
Molecular Formula
C21H31ClN6O3
Molecular Weight
450.96
References & Citations
[1]Mohler MA, et, al. D-Phe-Pro-Arg-chloromethylketone: its potential use in inhibiting the formation of in vitro artifacts in blood collected during tissue-type plasminogen activator thrombolytic therapy. Thromb Haemost. 1986 Oct 21;56 (2) :160-4.|[2]Lyon ME, et, al. D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone (PPACK) : alternative anticoagulant to heparin salts for blood gas and electrolyte specimens. Clin Chem. 1995 Jul;41 (7) :1038-41.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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