PPACK

• Description:

  PPACK is potent, selective and irreversible thrombin inhibitor. PPACK can be used an alternative anticoagulant to lithium heparin (LiHep) for blood gas and whole-blood electrolyte analyses. PPACK is also a plasminogen activator (rt-PA) inhibitor. PPACK can inhibit the binding of rt-PA to plasma protease inhibitors[1][2].

• UNSPSC:

  12352209

• Target:

  PAI-1; Thrombin

• Type:

  Peptides

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/ppack.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (N1[C@@H] (CCC1) C (N[C@@H] (CCCNC (N) =N) C (CCl) =O) =O) [C@@H] (CC2=CC=CC=C2) N

• Molecular Formula:

  C21H31ClN6O3

• Molecular Weight:

  450.96

• References & Citations:

  [1]Mohler MA, et, al. D-Phe-Pro-Arg-chloromethylketone: its potential use in inhibiting the formation of in vitro artifacts in blood collected during tissue-type plasminogen activator thrombolytic therapy. Thromb Haemost. 1986 Oct 21;56 (2) :160-4.|[2]Lyon ME, et, al. D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone (PPACK) : alternative anticoagulant to heparin salts for blood gas and electrolyte specimens. Clin Chem. 1995 Jul;41 (7) :1038-41.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  71142-71-7