PPACK

• Description :

  PPACK is potent, selective and irreversible thrombin inhibitor. PPACK can be used an alternative anticoagulant to lithium heparin (LiHep) for blood gas and whole-blood electrolyte analyses. PPACK is also a plasminogen activator (rt-PA) inhibitor. PPACK can inhibit the binding of rt-PA to plasma protease inhibitors[1][2].

• CAS Number :

  [71142-71-7]

• UNSPSC :

  12352209

• Target :

  PAI-1; Thrombin

• Type :

  Peptides

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/ppack.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N1[C@@H](CCC1)C(N[C@@H](CCCNC(N)=N)C(CCl)=O)=O)[C@@H](CC2=CC=CC=C2)N

• Molecular Formula :

  C21H31ClN6O3

• Molecular Weight :

  450.96

• References & Citations :

  [1]Mohler MA, et, al. D-Phe-Pro-Arg-chloromethylketone: its potential use in inhibiting the formation of in vitro artifacts in blood collected during tissue-type plasminogen activator thrombolytic therapy. Thromb Haemost. 1986 Oct 21;56 (2) :160-4.|[2]Lyon ME, et, al. D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone (PPACK) : alternative anticoagulant to heparin salts for blood gas and electrolyte specimens. Clin Chem. 1995 Jul;41 (7) :1038-41.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported