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Anti-Pro/Actived Complement C1s Antibody

CAT: 1303-ABS 002-49-04Size: 400 uLDry Ice: NoHazardous: No
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CAT#:1303-ABS 002-49-04Size:400 uL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
C1s proenzyme is a 79.8 kDa glycoprotein produced primarily by hepatocytes but also by other cells. The proenzyme is produced as a single-chain polypeptide of 688 aa. Upon activation the peptide is cleaved between R437 and I438 giving the activated enzyme consisting of two disulfide-linked chains, A chain (52.2 kDa) and B chain (27.7 kDa) . The Ca-dependent catalytic subunit of the C1 complex (C1q, C1r, C1s) comprises of two C1s and two C1r molecules and this serine protease tetramer is responsible for the initial steps in the classical complement pathway, cleavage of C4 and C2.
Description
Our mouse Pro/Actived Complement C1s monoclonal antibody from Antibodies Incorporated is produced in-house from clone 49. It detects human Pro/Actived Complement C1s and is Protein A or Protein G purified. Works in ELISA, IF.
Synonyms
C1S, EDSPD2, complement C1s subcomponent, C1 esterase, basic proline-rich peptide IB-1, complement component 1 subcomponent s, complement component 1, s subcomponent
Gene Name
C1S
NCBI Gene ID
716
UniProt
P09871
Host
Mouse
Reactivity
Human
Immunogen
Human plasma C1s Proenzyme
Target
Pro/Actived Complement C1s
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
49
Type
Primary Antibodies
Applications
ELISA, IF
Concentration
1 mg/mL ±15%
Format
Protein A or Protein G purified
Buffer
0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide
Molecular Weight
Pro-enzyme C1s (pro-C1s) appears as a single-chain polypeptide around 80 kDa. Upon activation, it is cleaved into two disulfide-linked chains: a ~57 kDa A-chain and and 27 kDa B-chain) .
Shipping Conditions
Shipped on ice packs
Storage Conditions
2-8°C without exposure to light
Notes
BSA free
IHC Dilution
0.04861111111111111
Specificity
ABS 002-49 is specific for C1s proenzyme and activated free C1s and C1s in complex with C1 inhibitor. Epitope differs from that of ABS 002-09.
Brand
Antibodies Inc (via BioPorto acquisition)
Recommended Usage
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
Physical Properties
Liquid
Immunogen Species
Human

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