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NMDAR/TRPM4-IN-2

CAT: 0931-T72662-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T72662-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2243506-33-2
Target
TRP/TRPV Channel, iGluR, ERK, NMDAR
Related Pathways
Membrane transporter/Ion channel, Neuroscience, MAPK
Purity
0.9975
Bioactivity
NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss in mice.NMDAR/TRPM4-IN-2 has neuroprotective activity against NMDA-induced hippocampal neuronal cell death and mitochondrial dysfunction. NMDAR/TRPM4-IN-2 showed neuroprotective activity against NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons with an IC50 value of 2.1 μM.
Smiles
Cl.Cl.CCN(CCN)Cc1cccc(Br)c1
Molecular Formula
C11H19BrCl2N2
Molecular Weight
330.092
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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