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Hydroquinine

CAT: 0804-HY-42034-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-42034-01Size:1 g
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Description
Hydroquinine (Dihydroquinine) is an anti-bacterial agent that inhibits both Gram-positive and Gram-negative bacteria. Hydroquinine inhibits the growth of multidrug-resistant pseudomonas aeruginosa via the suppression of the arginine deiminase pathway genes. Hydroquinine inhibits Plasmodium falciparum and Plasmodium berghei. Hydroquinine displays anti-malarial and demelanizing activities. Hydroquinine effectively induces specific RND-type efflux pump systems in Pseudomonas aeruginosa, particularly the MexCD-OprJ and MexXY efflux pumps. Hydroquinine inhibits Pseudomonas aeruginosa adhesion and biofilm formation. Hydroquinine serves as a precursor for derivatives such as C9 epihydroquinine, 9-acetoxy-10,11-dihydroquinine, and 10,11-dihydroquinine monohydrochloride[1][2][3].
CAS Number
522-66-7
Product Name Alternative
Dihydroquinine
UNSPSC
12352005
Hazard Statement
H315, H317, H319, H334, H335
Target
Bacterial; Parasite; Protein Arginine Deiminase; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Anti-infection; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/hydroquinine.html
Purity
99.84
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
CC[C@@H]1[C@@H]2C[C@H]([N@](C1)CC2)[C@H](O)C3=CC=NC4=CC=C(OC)C=C43
Molecular Formula
C20H26N2O2
Molecular Weight
326.44
Precautions
H315, H317, H319, H334, H335
References & Citations
[1]Weawsiangsang S, et al. Hydroquinine Inhibits the Growth of Multidrug-Resistant Pseudomonas aeruginosa via the Suppression of the Arginine Deiminase Pathway Genes. Int J Mol Sci. 2023 Sep 10;24 (18) :13914. |[2]Rattanachak N, et al. Hydroquinine Possesses Antibacterial Activity, and at Half the MIC, Induces the Overexpression of RND-Type Efflux Pumps Using Multiplex Digital PCR in Pseudomonas aeruginosa. Trop Med Infect Dis. 2022 Jul 30;7 (8) :156. |[3]Weawsiangsang S, et al. Hydroquinine Enhances the Efficacy of Contact Lens Solutions for Inhibiting Pseudomonas aeruginosaAdhesion and Biofilm Formation. Antibiotics (Basel) . 2024 Jan 5;13 (1) :56. |[4]Huffman AM, et al. Inhibition of Toxoplasma gondii Growth by Dihydroquinine and Its Mechanisms of Action. Front Cell Infect Microbiol. 2022 May 11;12:852889.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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