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Hydroquinidine

CAT: 0804-HY-B0997-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-B0997-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Hydroquinidine (Dihydroquinidine) is a potent ion channel blocker, which exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells. Hydroquinidine prolongs the QT interval and has antiarrhythmic efficacy[1][2][3][4][5].
CAS Number
1435-55-8
Product Name Alternative
Dihydroquinidine; (+) -Hydroquinidine; Hydroconquinine
UNSPSC
12352005
Hazard Statement
H302
Target
Others
Type
Natural Products
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Hydroquinidine.html
Purity
99.97
Solubility
DMSO : 20.83 mg/mL (ultrasonic)
Smiles
O[C@@H](C1=CC=NC2=C1C=C(OC)C=C2)[C@]3([H])[N@](C[C@@H]4CC)CC[C@H]4C3
Molecular Formula
C20H26N2O2
Molecular Weight
326.44
Precautions
H302
References & Citations
[1]Mazzanti A, et, al. Hydroquinidine Prevents Life-Threatening Arrhythmic Events in Patients With Short QT Syndrome. J Am Coll Cardiol. 2017 Dec 19;70 (24) :3010-3015.|[2]Hermida JS, et, al. Hydroquinidine therapy in Brugada syndrome. J Am Coll Cardiol. 2004 May 19;43 (10) :1853-60.|[3]Chimienti M, et, al. Comparison of the effectiveness of dihydroquinidine and quinidine on ventricular ectopy after acute and chronic administration. Cardiovasc Drugs Ther. 1988 Dec;2 (5) :679-86.|[4]Mazzanti A, et al. Hydroquinidine Prevents Life-Threatening Arrhythmic Events in Patients With Short QT Syndrome. J Am Coll Cardiol. 2017 Dec 19;70 (24) :3010-3015. |[5]Yavuz M, et al. A potent ion channel blocker, hydroquinidine, exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells. Mol Biol Rep. 2023 Mar;50 (3) :2611-2621.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched

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