TES-991

• Description:

  TES-991 is a potent and selective human α Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) inhibitor, with an IC50 of 3 nM.

• UNSPSC:

  12352005

• Target:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/TES-991.html

• Purity:

  99.65

• Solubility:

  DMSO : 62.5 mg/mL (ultrasonic)

• Smiles:

  N#CC1=C (C2=CC=CS2) NC (SCC3=CC=CC (C4=NN=NN4) =C3) =NC1=O

• Molecular Formula:

  C17H11N7OS2

• Molecular Weight:

  393.45

• References & Citations:

  [1]Pellicciari R, et al. α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD+) Biosynthesis. J Med Chem. 2018 Feb 8;61 (3) :745-759.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1883602-20-7