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PBIP1 rabbit pAb

CAT: 0855-ES14243-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES14243-01Size:50 µL
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Background
The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined. [provided by RefSeq, Dec 2015]
Description
The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined. [provided by RefSeq, Dec 2015],
UniProt
Q96AQ6
Swiss Prot
Q96AQ6
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human PBIP1 AA range: 585-635
Target
PBIP1
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasm, cytoskeleton . Nucleus . Shuttles between the nucleus and the cytosol (PubMed:12360403) . Mainly localized in the cytoplasm, associated with microtubules (PubMed:10825160, PubMed:12360403) . Detected in small amounts in the nucleus (PubMed:10825160) .
Gene ID (Human)
57326

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