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PBIP1 rabbit pAb

CAT: 0855-ES14243-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES14243-01Size:50 µL
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Background
The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined. [provided by RefSeq, Dec 2015]
Description
The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined. [provided by RefSeq, Dec 2015],
UniProt
Q96AQ6
Swiss Prot
Q96AQ6
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human PBIP1 AA range: 585-635
Target
PBIP1
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasm, cytoskeleton . Nucleus . Shuttles between the nucleus and the cytosol (PubMed:12360403) . Mainly localized in the cytoplasm, associated with microtubules (PubMed:10825160, PubMed:12360403) . Detected in small amounts in the nucleus (PubMed:10825160) .
Gene ID (Human)
57326

UniProtKB · Q96AQ6

Pre-B-cell leukemia transcription factor-interacting protein 1

PBIP1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q96AQ6
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PBXIP1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q5T174, Q5T176, Q9H8X6, Q9HA02, Q9HD85
Protein keywords

Coding sequence diversity

Alternative splicing

Domain

Coiled coil

Cellular component

CytoplasmCytoskeletonMicrotubuleNucleus

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

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