Products for Research Use Only
RegisterLogin

Duocarmycin DM (free base)

CAT: 0804-HY-128915-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-128915-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Duocarmycin DM free base, a DNA minor-groove alkylator, is an antibody agent conjugates (ADCs) toxin. Duocarmycin DM free base is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity[1][2].
CAS Number
1116745-06-2
UNSPSC
12352203
Target
ADC Payload; DNA Alkylator/Crosslinker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/duocarmycin.html
Purity
99.69
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N1C[C@@H](CCl)C2=C1C=C(O)C3=CC=CC=C23)C(N4)=CC5=C4C=CC(OCCN(C)C)=C5
Molecular Formula
C26H26ClN3O3
Molecular Weight
463.96
References & Citations
[1]Patil PC, et al. A Short Review on the Synthetic Strategies of Duocarmycin Analogs that are Powerful DNA Alkylating Agents. Anticancer Agents Med Chem. 2015;15 (5) :616-630.|[2]Koch MF, et al. Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues. Angew Chem Int Ed Engl. 2015 Nov 9;54 (46) :13550-4.|[3]Chen KC, et al. Selective cancer therapy by extracellular activation of a highly potent glycosidic duocarmycin analogue. Mol Pharm. 2013;10 (5) :1773-1782.|[4]Chen KC, Schmuck K, Tietze LF, Roffler SR. Selective cancer therapy by extracellular activation of a highly potent glycosidic duocarmycin analogue. Mol Pharm. 2013;10 (5) :1773-1782.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Daunorubicins/Doxorubicins

Related Products

CatalogName
HY-130978-01Duocarmycin DM
HY-160143G3-VC-PAB-DMEA-Duocarmycin DM
HY-157465-01MA-PEG4-VC-PAB-DMEA-duocarmycin DM
HY-157465A-01MA-PEG4-VC-PAB-DMEA-duocarmycin DM (TFA)
HY-109118Masupirdine (free base)
HY-152852-01Mefatinib (free base)
HY-19651-01Zanapezil (free base)
HY-116031ATC0175 (free base)
HY-120421SW116 (free base)
HY-139806SRA880 (free base)

Alternative Products

CatalogName
T11119-01Duocarmycin DM free base
TB0954TMB free base
A8893-10Rucaparib (free base)
FX56092-01Xylazine - free base
T-8100-01Tryptamine, free base
XN175452-01Norharman - free base
MBS5779607Amidantel free base
533249ML355 free base
414310Neamine Free Base
596942Carnosine free base

Popular Products