Products for Research Use Only
RegisterLogin

DC-Y13-27

CAT: 0804-HY-154919-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-154919-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
DC-Y13-27 is a DC-Y13 derivative and YTHDF2 inhibitor (KD: 37.9 μM) . DC-Y13-27 inhibits YTHDF2, restores FOXO3 and TIMP1 protein levels, and reduces MMP1/3/7/9 expression. DC-Y13-27 induces Pyroptosis and increases IL-1β secretion. DC-Y13-27 reduces intervertebral disc degeneration and enhances the response to radiotherapy in colon cancer and melanoma. DC-Y13-27 has antitumor activity against breast cancer[1][2][3].
UNSPSC
12352005
Target
FOXO; Interleukin Related; MMP; Pyroptosis; YTHDF
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/dc-y13-27.html
Purity
99.52
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N#C/C(C(N)=O)=C\C1=CC=C(C2=CC(O)=CC=C2)S1
Molecular Formula
C14H10N2O2S
Molecular Weight
270.31
References & Citations
[1]Wang L, et al. YTHDF2 inhibition potentiates radiotherapy antitumor efficacy. Cancer Cell. 2023 May 15:S1535-6108 (23) 00163-0.|[2]Wang F, et al. YTHDF2-dependent m6A modification of FOXO3 mRNA mediates TIMP1 expression and contributes to intervertebral disc degeneration following ROS stimulation. Cell Mol Life Sci. 2024 Dec 3;81 (1) :477.|[3]Shuai Y, et al. The N6-methyladenosine writer METTL3 promotes breast cancer progression through YTHDF2-dependent posttranscriptional silencing of GSDMD. Apoptosis. 2025 Feb;30 (1-2) :226-238.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
FOXO3; IL-1; MMP-1; MMP-3; MMP-7; MMP-9; YTHDF2

Related Products

CatalogName
HY-176848-01SKLB-Y13
HY-160477-01DC-SX029
HY-177944DC-PGKI
HY-147209DC-TEAD3in03
HY-129427DC-015
HY-121093-01DC-S239
HY-119164DC-S238
HY-43643-01DC-5163
HY-150505-01DC-U4106
HY-159955DC-159a

Alternative Products

CatalogName
BUP05527-01DC-Y13-27
TBI4884-25MGDC-Y13-27, YTHDF2 inhibitor
GTR19272971-01SKLB-Y13
GTR18089731Anti-p21 [Y13-238]
A110532Anti-CDK6-Y13 (Rabbit)
MBS8574459-01Phospho-CDK6-Y13 pAb
OAAV01173-200UGP21 Recombinant Antibody [Y13-238]
MBS128340-01Phospho-CDK6-Y13 Polyclonal Antibody
E45R00899N-100Phospho-CDK6-Y13 Rabbit pAb
RD268132A-01Phospho-CDK6(Y13) Polyclonal Antibody

Popular Products