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NSC 405020

CAT: 0804-HY-15827-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15827-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NSC 405020 is a specific MMP14 inhibitor. NSC 405020 can directly interact with the hemopexin domain of MMP14. NSC 405020 reduces the expression of full length and active cleaved Notch3 (NICD3) . NSC 405020 can be used to research vestibular schwannoma, hemostasis and thrombosis[1][2][3].
CAS Number
7497-07-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/NSC-405020.html
Purity
99.63
Solubility
DMSO : ≥ 260 mg/mL
Smiles
O=C(NC(C)CCC)C1=CC=C(Cl)C(Cl)=C1
Molecular Formula
C12H15Cl2NO
Molecular Weight
260.16
Precautions
H302, H315, H319, H335
References & Citations
[1]Ren Y, et al. MMP-14 (MT1-MMP) Is a Biomarker of Surgical Outcome and a Potential Mediator of Hearing Loss in Patients With Vestibular Schwannomas. Front Cell Neurosci. 2020 Jul 28;14:191.|[2]Pekkonen P, et al. Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation. Elife. 2018 May 1;7:e32490.|[3]Mastenbroek TG, et al. Platelet-Associated Matrix Metalloproteinases Regulate Thrombus Formation and Exert Local Collagenolytic Activity. Arterioscler Thromb Vasc Biol. 2015 Dec;35 (12) :2554-61.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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4902/10NSC 405020
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A13072-100NSC 405020 100mg

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