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Indantadol (hydrochloride)

CAT: 0804-HY-101440A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101440A-01Size:1 mg
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Description
Indantadol hydrochloride (CHF-3381) is an orally active, non-selective NMDA antagonist and MAO inhibitor. Indantadol hydrochloride blocks the binding of [³H]-MK-801 to NMDA receptors in a non-competitive manner, with an IC50 of 8.1 μM. Indantadol hydrochloride completely inhibits dopamine release caused by NMDA. Indantadol hydrochloride protects neurons, with an ED₅₀ of 35 μM. Indantadol hydrochloride has anticonvulsant and anti-high pain hypersensitivity activities[1][2][3].
CAS Number
202914-18-9
Product Name Alternative
CHF-3381
UNSPSC
12352005
Target
IGluR; Monoamine Oxidase
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/indantadol-hydrochloride.html
Smiles
O=C(CNC1CC2=C(C1)C=CC=C2)N.Cl
Molecular Formula
C11H15ClN2O
Molecular Weight
226.70
References & Citations
[1]Silvia Zucchini, et al. Neuroprotective activity of CHF3381, a putative N-methyl-D-aspartate receptor antagonist. Neuroreport. 2022, 13, 6.|[2]Gandolfi O, et al. Anticonvulsant preclinical profile of CHF 3381: dopaminergic and glutamatergic mechanisms. Pharmacol Biochem Behav. 2001 Sep;70 (1) :157-66. |[3]Mattia C, Coluzzi F. Indantadol, a novel NMDA antagonist and nonselective MAO inhibitor for the potential treatment of neuropathic pain. IDrugs. 2007 Sep;10 (9) :636-44.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
NMDA Receptor

Chemical Information

Indantadol hydrochloride
CAS Number202914-18-9
PubChem CID10198454
IUPAC Name2-(2,3-dihydro-1H-inden-2-ylamino)acetamide;hydrochloride
Molecular FormulaC11H15ClN2O
Molecular Weight226.70
Topological Polar Surface Area55.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Heavy Atom Count15
Formal Charge0
Complexity203
SMILES
C1C(CC2=CC=CC=C21)NCC(=O)N.Cl
InChI
InChI=1S/C11H14N2O.ClH/c12-11(14)7-13-10-5-8-3-1-2-4-9(8)6-10;/h1-4,10,13H,5-7H2,(H2,12,14);1H
InChIKey
JPNNIRXUJSPGRM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Indantadol hydrochloride
CAS: 202914-18-9
CID: 10198454
Formula: C11H15ClN2O
MW: 226.70
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight226.70
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Exact Mass226.0872908
Monoisotopic Mass226.0872908
Topological Polar Surface Area55.1 Ų
Heavy Atom Count15
Formal Charge0
Complexity203
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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