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Indantadol

CAT: 0804-HY-101440Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101440Size:1 Each
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Description
Indantadol (the free base of CHF-3381) is an orally active, non-selective NMDA antagonist and MAO inhibitor. Indantadol blocks the binding of [³H]-MK-801 to NMDA receptors in a non-competitive manner, with an IC50 of 8.1 μM. Indantadol completely inhibits dopamine release caused by NMDA. Indantadol protects neurons, with an ED₅₀ of 35 μM. Indantadol has anticonvulsant and anti-high pain hypersensitivity activities[1][2][3].
CAS Number
202844-10-8
Product Name Alternative
CHF-3381 (free base)
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
IGluR; Monoamine Oxidase
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(N)CNC1CC2=C(C=CC=C2)C1
Molecular Formula
C11H14N2O
Molecular Weight
190.24
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Silvia Zucchini, et al. Neuroprotective activity of CHF3381, a putative N-methyl-D-aspartate receptor antagonist. Neuroreport. 2022, 13, 6.|[2]Mattia C, Coluzzi F. Indantadol, a novel NMDA antagonist and nonselective MAO inhibitor for the potential treatment of neuropathic pain. IDrugs. 2007 Sep;10 (9) :636-44. |[3]Gandolfi O, et al. Anticonvulsant preclinical profile of CHF 3381: dopaminergic and glutamatergic mechanisms. Pharmacol Biochem Behav. 2001 Sep;70 (1) :157-66.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Isoform
NMDA Receptor

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CatalogName
MBS5777315Indantadol HCl

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