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AZD8421

CAT: 0804-HY-158106-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-158106-01Size:5 mg
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Description
AZD8421 is a selective CDK2 inhibitor (IC50 = 9 nM) as well as achieving CDK family selectivity in cells versus key off-targets (CDK1, CDK4/6, CDK9), AZD8421 had no significant kinase inhibition outside the CDK family. AZD8421 inhibits cancer cell proliferation by inhibiting pRB phosphorylation, inducing cell cycle arrest in G1/S phase and senescence. AZD8421 can be studied in research for breast cancer and ovarian cancer[1].
CAS Number
[3047321-53-6]
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azd8421.html
Concentration
10mM
Purity
99.60
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCN1C=NC2=C1N=C(N[C@@H](CC)[C@@H](C)O)N=C2N[C@@H]3CN(S(=O)(NCC)=O)CC3
Molecular Formula
C18H32N8O3S
Molecular Weight
440.56
References & Citations
[1]Denz C R, et al. Targeting the cell cycle with AZD8421, a potent and highly selective CDK2 inhibitor[J]. Cancer Research, 2024, 84 (6_Supplement) : 5730-5730.|[2]Kudo, R., et al., (2024) . Long-term breast cancer response to CDK4/6 inhibition defined by TP53-mediated geroconversion. Cancer cell, 42 (11), 1919–1935.e9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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