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AZD8421

CAT: 0931-T201366-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T201366-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3047321-53-6
Bioactivity
AZD8421 is a potent and highly selective inhibitor of cyclin-dependent kinase 2 (CDK2) with an IC50 of 9nM, demonstrating greater selectivity over CDK1, CDK4, and CDK6. This compound also exhibits antiproliferative properties by effectively inhibiting Rb phosphorylation. In models of breast and ovarian cancer, AZD8421 has shown significant activity both as a monotherapy and in combination with CDK4/6 inhibitors.
Smiles
N(C1=C2C(N(CC)C=N2)=NC(N[C@H]([C@@H](C)O)CC)=N1)[C@@H]3CN(S(NCC)(=O)=O)CC3
Molecular Formula
C18H32N8O3S
Molecular Weight
440.56
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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C01989-01AZD8421
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