Products for Research Use Only
RegisterLogin

AZD0424

CAT: 0804-HY-112314Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-112314Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
AZD0424 is an orally active, and dual selective Src/Abl kinase inhibitor with potential antineoplastic activity[1]. AZD0424 induces apoptosis and cell cycle arrest in lymphoma cells[2].
CAS Number
692054-06-1
UNSPSC
12352005
Target
Apoptosis; Bcr-Abl; Src
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azd0424.html
Solubility
10 mM in DMSO
Smiles
CC(N1CCN(CCOC2=CC3=NC=NC(NC4=C(OCO5)C5=NC=C4Cl)=C3C(OC(C)C)=C2)CC1)=O
Molecular Formula
C25H29ClN6O5
Molecular Weight
528.99
References & Citations
[1]Woodcock VK, et al. A first-in-human phase I study to determine the maximum tolerated dose of the oral Src/ABL inhibitor AZD0424. Br J Cancer. 2018 Mar 20;118 (6) :770-776.|[2]Nowak D, et al. Src kinase inhibitors induce apoptosis and mediate cell cycle arrest in lymphoma cells. Anticancer Drugs. 2007 Oct;18 (9) :981-95.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

Related Products

CatalogName
HY-158106-01AZD8421
HY-108243-01AZD5423
HY-103672-01AZD7624
HY-173637-01AZD0022
HY-116507AZD0328
HY-135891-01AZD2423
HY-173637A(S) -AZD0022

Alternative Products

CatalogName
T14370-01AZD0424
A19488-1AZD0424 1mg
A19488-100AZD0424 100mg
A19488-50AZD0424 50mg
A19488-10AZD0424 10mg
A19488-25AZD0424 25mg
A19488-5AZD0424 5mg

Popular Products