17(R)-Resolvin D1

• Product Name Alternative:

  17(R)-RvD1; AT-RvD1

• UNSPSC Description:

  17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells[1]. 17R-Resolvin D1 specificially inhibits TRPV3 with an IC50 of 398 nM and exhibits peripheral anti-nociceptive efficacy[2].

• Target Antigen:

  TRP Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/17-r-resolvin-d1.html

• Purity:

  99.1

• Solubility:

  10 mM in DMSO

• Smiles:

  CC/C=C\C[C@@H](O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)C/C=C\CCC(O)=O

• Molecular Weight:

  376.49

• References & Citations:

  [1]Sun YP, et al., Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. J Biol Chem. 2007 Mar 30;282(13):9323-9334.|[2]Bang S, et al., 17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception. Br J Pharmacol. 2012 Feb;165(3):683-92.

• Shipping Conditions:

  Dry Ice

• Storage Conditions:

  -80°C, protect from light

• Clinical Information:

  No Development Reported

• CAS Number:

  528583-91-7