NADPH

• Product Name Alternative:

  EPZ015866; GSK3203591

• UNSPSC Description:

  NADPH is an essential electron donor in organisms, providing reducing power for anabolic reactions and redox balance, with potential applications in electrosynthesis. The cellular NADPH homeostasis is associated with tumorigenesis. As a key factor in the cellular antioxidant system, NADPH can mediate cell death through its effects on oxidative stress. This approach, based on NADPH-regulated metabolism, holds promise for research in the field of cancer therapy[1][2][3].

• Target Antigen:

  Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nadph.html

• Purity:

  99.49

• Solubility:

  H2O : 116.67 mg/mL (ultrasonic)

• Smiles:

  O=P(O)(O)O[C@H]1[C@H](N2C3=NC=NC(N)=C3N=C2)O[C@@H]([C@H]1O)COP(OP(OC[C@H]4O[C@@H](N5C=C(CC=C5)C(N)=O)[C@@H]([C@@H]4O)O)(O)=O)(O)=O

• Molecular Weight:

  745.42

• References & Citations:

  [1]Chong-Chan Kim, et al. An Implantable Ionic Wireless Power Transfer System Facilitating Electrosynthesis. ACS Nano. 2020 Sep 22;14(9):11743-11752.|[2]Ju HQ et al. NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications. Signal Transduct Target Ther. 2020 Oct 7;5(1):231.|[3]Xia W, et al. Roles of NAD+/NADH and NADP+/NADPH in cell death[J]. Current Pharmaceutical Design, 2009, 15(1): 12-19.J Agric Food Chem. 2024 Aug 28.|Chem Biol Interact. 2022 Oct 13;110222.|Drug Des Dev Ther. 2020 Nov 30;14:5259-5273.|Eur J Pharm Sci. 2021, 105889.|iScience. 2024 Aug 30;27(9):110834.|JID Innov. 2023 Nov 28, 100251.|Microbiol Spectr. 2023 Sep 21;e0267123.|Mol Ther Oncol. 2024 Sep 17;32(4):200878.|Research Square Preprint. 2023 Jul 31.|Xenobiotica. 04 Jan 2022.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Clinical Information:

  No Development Reported

• CAS Number:

  53-57-6