NADPH

• Description:

  NADPH is a coenzyme of glutathione reductase (GR), thioredoxin reductase (TrxR) and NADPH oxidase (NOX), and participates in redox reactions as a hydrogen donor. NADPH has the characteristic of selectively participating in the regulation of cellular redox homeostasis. NADPH exerts antioxidant activity and resists reactive oxygen species (ROS) damage by providing reducing equivalents for the regeneration of glutathione (GSH) and thioredoxin (Trx) ; at the same time, it acts as a substrate of NOX to generate superoxide anions, mediating oxidative stress and immune response. NADPH participates in maintaining the intracellular reducing environment, biosynthesis and regulating gene expression (such as the Nrf2 pathway), and is mainly used in the study of oxidative stress-related diseases (such as cardiovascular diseases, neurodegenerative diseases, cancer) and immune regulation mechanisms[1][2].

• Product Name Alternative:

  EPZ015866; GSK3203591

• UNSPSC:

  12352005

• Target:

  Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nadph.html

• Purity:

  99.75

• Solubility:

  H2O : 116.67 mg/mL (ultrasonic)

• Smiles:

  O=P(O)(O)O[C@H]1[C@H](N2C3=NC=NC(N)=C3N=C2)O[C@@H]([C@H]1O)COP(OP(OC[C@H]4O[C@@H](N5C=C(CC=C5)C(N)=O)[C@@H]([C@@H]4O)O)(O)=O)(O)=O

• Molecular Formula:

  C21H30N7O17P3

• Molecular Weight:

  745.42

• References & Citations:

  [1]Xia W, et al. Roles of NAD (+) /NADH and NADP (+) /NADPH in cell death. Curr Pharm Des. 2009;15 (1) :12-9.|[2]Pollak N, et al. NAD kinase levels control the NADPH concentration in human cells. J Biol Chem. 2007 Nov 16;282 (46) :33562-33571.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  Human Endogenous Metabolite

• Citation 01:

  Adv Sci (Weinh) . 2025 Sep 15:e07283.|J Agric Food Chem. 2024 Sep 11;72 (36) :20064-20076.|Cell Rep Phys Sci. 2025 Mar 19.|Chem Biol Interact. 2022 Dec 1:368:110222.|Chemrxiv. 2025 Aug 28.|Drug Des Devel Ther. 2020 Nov 30;14:5259-5273.|Eur J Pharm Sci. 2021 Sep 1:164:105889.|iScience. 2024 Aug 30;27 (9) :110834.|JID Innov. 2023 Nov 28;4 (2) :100251.|Microbiol Spectr. 2023 Sep 21;11 (5) :e0267123.|Mol Ther Oncol. 2024 Sep 17;32 (4) :200878.|Research Square Preprint. 2023 Jul 31.|Xenobiotica. 2022 Feb;52 (2) :165-176.

• CAS Number:

  [53-57-6]