NADPH

CAT: 0804-HY-113324-01Size: 50 mgDry Ice: NoHazardous: No
CAT#:0804-HY-113324-01Size:50 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
NADPH is a coenzyme of glutathione reductase (GR), thioredoxin reductase (TrxR) and NADPH oxidase (NOX), and participates in redox reactions as a hydrogen donor. NADPH has the characteristic of selectively participating in the regulation of cellular redox homeostasis. NADPH exerts antioxidant activity and resists reactive oxygen species (ROS) damage by providing reducing equivalents for the regeneration of glutathione (GSH) and thioredoxin (Trx) ; at the same time, it acts as a substrate of NOX to generate superoxide anions, mediating oxidative stress and immune response. NADPH participates in maintaining the intracellular reducing environment, biosynthesis and regulating gene expression (such as the Nrf2 pathway), and is mainly used in the study of oxidative stress-related diseases (such as cardiovascular diseases, neurodegenerative diseases, cancer) and immune regulation mechanisms[1][2].
CAS Number
[53-57-6]
Product Name Alternative
EPZ015866; GSK3203591
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nadph.html
Purity
99.75
Solubility
H2O : 116.67 mg/mL (ultrasonic)
Smiles
O=P(O)(O)O[C@H]1[C@H](N2C3=NC=NC(N)=C3N=C2)O[C@@H]([C@H]1O)COP(OP(OC[C@H]4O[C@@H](N5C=C(CC=C5)C(N)=O)[C@@H]([C@@H]4O)O)(O)=O)(O)=O
Molecular Formula
C21H30N7O17P3
Molecular Weight
745.42
References & Citations
[1]Xia W, et al. Roles of NAD (+) /NADH and NADP (+) /NADPH in cell death. Curr Pharm Des. 2009;15 (1) :12-9.|[2]Pollak N, et al. NAD kinase levels control the NADPH concentration in human cells. J Biol Chem. 2007 Nov 16;282 (46) :33562-33571.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite
Citation 01
Adv Sci (Weinh) . 2025 Sep 15:e07283.|J Agric Food Chem. 2024 Sep 11;72 (36) :20064-20076.|Cell Rep Phys Sci. 2025 Mar 19.|Chem Biol Interact. 2022 Dec 1:368:110222.|Chemrxiv. 2025 Aug 28.|Drug Des Devel Ther. 2020 Nov 30;14:5259-5273.|Eur J Pharm Sci. 2021 Sep 1:164:105889.|iScience. 2024 Aug 30;27 (9) :110834.|JID Innov. 2023 Nov 28;4 (2) :100251.|Microbiol Spectr. 2023 Sep 21;11 (5) :e0267123.|Mol Ther Oncol. 2024 Sep 17;32 (4) :200878.|Research Square Preprint. 2023 Jul 31.|Xenobiotica. 2022 Feb;52 (2) :165-176.

Related Products

CatalogName
HY-113325-01NADP
HY-113355NADH
HY-113325R-01NADP (Standard)
HY-154924Thio-NADP
HY-146036-01NADH-IN-1
HY-168146NADH-IN-2
HY-154925Thio-NADH
HY-175016NADH-IN-3
HY-P3182NADH oxidase
HY-F0002A-01NADP (disodium salt)

Alternative Products

CatalogName
ST360-1gNADPH
YP-W79177-01Sheep NADPH (NADPH) ELISA Kit
YP-W24578-01Mouse NADPH (NADPH) ELISA Kit
Y123140Anti-NADPH
GC303011-100mgNADPH-Na4
MA-0126NADP/NADPH
E551021-1-PUNADPH Antibody
M22481-01NADPH (tetracyclohexanamine)
MF-0110055-01NADPH tetracyclohexanamine
abx082152-01NADPH Na4

Popular Products