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NADH-IN-3

CAT: 0804-HY-175016Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175016Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NADH-IN-3 (Compound C4-1) is a NADH inhibitor with a MIC of 4 μg/mL (13.042 μM) for type II NADH dehydrogenase of Mycobacterium tuberculosis (Mtb). NADH-IN-3 significantly interrupts ATP synthesis, shows potent inhibitory effects against mono (Rifampicin and Isoniazid (HY-B0329) ) and multi drug-resistant (Mtb) strains and an anti-bactericidal activity against HepG2 cells with low cytotoxicity (SI: 16.52).
UNSPSC
12352005
Target
Endogenous Metabolite
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Infection; Metabolic Disease
Smiles
CC(C1=CC2=C(N=C(S2)SCC(NC3CC3)=O)C=C1)C
Molecular Formula
C15H18N2OS2
Molecular Weight
306.45
References & Citations
[1]Saha P, et al. Targeting drug-resistant tuberculosis: Thioacetamide-substituted benzothiazoles as bactericidal agents inhibiting type II NADH dehydrogenase. Bioorg Chem. 2025 Jul 3;163:108718.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Microbial Metabolite

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