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(E) -Dothiepin (hydrochloride)

CAT: 0804-HY-165378Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-165378Size:1 Each
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Description
(E) -Dothiepin ((E) -Dosulepin; (E) -Dothep) hydrochloride is an antidepressant agent with sedative/anxiolytic activity. (E) -Dothiepin hydrochloride is an inhibitor preferring of noradrenaline uptake than serotonin uptake. (E) -Dothiepin hydrochloride facilitates noradrenergic neurotransmission via inhibiting the neuronal uptake. (E) -Dothiepin hydrochloride is also an antagonist of histamine H1-receptor without cardiotoxicity. (E) -Dothiepin hydrochloride exhibits significant analgesic activity in psychogenic facial pain, idiopathic fibromyalgia syndrome or rheumatoid arthritis[1].
CAS Number
25627-36-5
Product Name Alternative
(E) -Dosulepin (hydrochloride) ; (E) -Dothep (hydrochloride)
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/e-dothiepin-hydrochloride.html
Smiles
CN(C)CC/C=C1C2=CC=CC=C2CSC3=CC=CC=C3\1.Cl
Molecular Formula
C19H22ClNS
Molecular Weight
331.90
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 4

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GP3558-1gDothiepin hydrochloride
BD164382Dothiepin hydrochloride - Bio-X TM
T78126-01Dothiepin
FD65010Dothiepin HCl
010957Dothiepin-d3
AR-D02313-01Dothiepin-13C-d3
447675-01Dothiepin-S, S-dioxide
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