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Dothiepin

CAT: 0804-HY-12394Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12394Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dothiepin (Dosulepin; Dothep) is an antidepressant agent with sedative/anxiolytic activity. Dothiepin is an inhibitor preferring of noradrenaline uptake than serotonin uptake. Dothiepin facilitates noradrenergic neurotransmission via inhibiting the neuronal uptake. Dothiepin is also an antagonist of histamine H1-receptor without cardiotoxicity. Dothiepin exhibits significant analgesic activity in psychogenic facial pain, idiopathic fibromyalgia syndrome or rheumatoid arthritis[1].
CAS Number
113-53-1
Product Name Alternative
Dosulepin; Dothep
UNSPSC
12352005
Hazard Statement
H302, H361, H362
Target
5-HT Receptor; Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dothiepin.html
Purity
98.22
Solubility
10 mM in DMSO
Smiles
CN(C)CC/C=C1C2=CC=CC=C2SCC3=CC=CC=C/13
Molecular Formula
C19H21NS
Molecular Weight
295.44
Precautions
H302, H361, H362
References & Citations
[1]Lancaster SG, et al. Dothiepin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs. 1989 Jul;38 (1) :123-47.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 4

Alternative Products

CatalogName
T78126-01Dothiepin
FD65010Dothiepin HCl
010957Dothiepin-d3
GP3558-1gDothiepin hydrochloride
AR-D02313-01Dothiepin-13C-d3
447675-01Dothiepin-S, S-dioxide
CS-O-46691Dothiepin Sulfoxide (E-isomer)
TRC-D536505-250MGDothiepin-S,S-dioxide
447676Dothiepin-S, S-dioxide-d3

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