(E/Z)-Icerguastat (hydrochloride)

(E/Z)-Icerguastat (hydrochloride)

• CAS Number: 32597-86-7
• UNSPSC Description: (E/Z)-Icerguastat hydrochloride ((E/Z)-Sephin1 hydrochloride) is a selective inhibitor with activity that prolongs the phosphorylation effects of eIF2α. (E/Z)-Icerguastat hydrochloride protects cells from defects in proteostasis. (E/Z)-Icerguastat hydrochloride was shown to significantly extend the survival of infected prion mice in a mouse model. (E/Z)-Icerguastat hydrochloride effectively reduces PrPSc expression and prion sequence activity in various neuronal cell lines persistently infected with different prion strains[1].
• Target Antigen: Phosphatase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/e-z-icerguastat-hydrochloride.html
• Smiles: ClC1=CC=CC=C1/C=N/NC(N)=N.Cl
• Molecular Weight: 233.10
• References & Citations: [1]Das I, et al. Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science. 2015 Apr 10;348(6231):239-42. |[2]Sephin1 Reduces Prion Infection in Prion-Infected Cells and Animal Model
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported