Wnt/β-catenin-IN-5

• UNSPSC Description:

  Wnt/β-catenin-IN-5 (Compound 4) is an inhibitor of the Wnt/β-catenin signaling pathway. Wnt/β-catenin-IN-5 eliminates colorectal cancer stem cells and inhibits tumor growth by suppressing the Wnt signaling pathway. PROTACs Wnt/β-catenin-IN-5, which is also a PROTAC based on IOX1, effectively induces the degradation of KDM3A and KDM3B (Target protein ligand (Pink): HY-12304; linker (Black): HY-22335; Conjugate of E3 ligase ligand and linker: HY-112599; E3 ligase (Blue): HY-41547)[1].

• Target Antigen:

  Histone Demethylase; PROTACs; β-catenin

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;PROTAC;Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/wnt-β-catenin-in-5.html

• Smiles:

  O=C(C1=C2C=CC=NC2=C(O)C=C1)NCCOCCOCCOCCOCCNC3=CC=CC(C(N4C(CC5)C(NC5=O)=O)=O)=C3C4=O

• Molecular Weight:

  663.67

• References & Citations:

  [1]Zaman S U, et al. Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling[J]. RSC Medicinal Chemistry, 2024.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported