Anticancer agent 223

• Description:

  Anticancer agent 223 (Compound V-d) is an anticancer agent that triggers cell death through caspase-dependent and caspase-independent mechanisms. Anticancer agent 223 inhibits tumor spheroid formation and resensitizes cisplatin (HY-17394) -resistant A2780 cells to cisplatin (HY-17394) treatment[1].

• UNSPSC:

  12352005

• Target:

  Caspase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/anticancer-agent-223.html

• Smiles:

  ClC1=CC=C(NC(C2CCN(C3=NC=NC4=C3C=CC=C4)CC2)=O)C=C1

• Molecular Formula:

  C20H19ClN4O

• Molecular Weight:

  366.84

• References & Citations:

  [1]Thuy Lu Vo T, et al. Design, synthesis and biological evaluation of novel quinazoline derivatives as immune checkpoint inhibitors. Bioorg Med Chem Lett. Published online May 15, 2024.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1328150-75-9]