Products for Research Use Only
RegisterLogin

ML213

CAT: 0804-HY-101843-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-101843-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ML213 is a selective activator of Kv7.2 and Kv7.4 channels, enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM, respectively.
CAS Number
489402-47-3
UNSPSC
12352005
Hazard Statement
H315, H319, H335, H413
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ML213.html
Purity
99.76
Solubility
DMSO : 36.67 mg/mL (ultrasonic)
Smiles
O=C(C1C(C2)CCC2C1)NC3=C(C)C=C(C)C=C3C
Molecular Formula
C17H23NO
Molecular Weight
257.37
Precautions
H315, H319, H335, H413
References & Citations
[1]Brueggemann LI, et al. Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673. Mol Pharmacol. 2014 Sep;86 (3) :330-41.|[2]Jepps TA, et al. Vasorelaxant effects of novel Kv 7.4 channel enhancers ML213 and NS15370. Br J Pharmacol. 2014 Oct;171 (19) :4413-24.|[3]Yu H, et al. Discovery, Synthesis, and Structure Activity Relationship of a Series of N-Aryl- bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener. ACS Chem Neurosci. 2011 Oct 19;2 (10) :572-577.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

ML213

N-(2,4,6-trimethylphenyl)-3-bicyclo[2.2.1]heptanecarboxamide is a monoterpenoid.

CAS Number489402-47-3
PubChem CID3111211
IUPAC NameN-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamide
Molecular FormulaC17H23NO
Molecular Weight257.37
XLogP4.2
Topological Polar Surface Area29.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Heavy Atom Count19
Formal Charge0
Complexity341
SMILES
CC1=CC(=C(C(=C1)C)NC(=O)C2CC3CCC2C3)C
InChI
InChI=1S/C17H23NO/c1-10-6-11(2)16(12(3)7-10)18-17(19)15-9-13-4-5-14(15)8-13/h6-7,13-15H,4-5,8-9H2,1-3H3,(H,18,19)
InChIKey
SIQGKPGBLYKQBB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of ML213
CAS: 489402-47-3
CID: 3111211
Formula: C17H23NO
MW: 257.37
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight257.37
XLogP34.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Exact Mass257.177964357
Monoisotopic Mass257.177964357
Topological Polar Surface Area29.1 Ų
Heavy Atom Count19
Formal Charge0
Complexity341
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count3
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-173018-01ML283
HY-19972ML243
HY-125976-01ML233
HY-103309-01ML218
HY-12342-01ML216
HY-179553(E) -ML233
HY-175633ML210-ansaFc
HY-103309S-01ML218-d9
HY-103309AML218 (hydrochloride)

Alternative Products

CatalogName
MBS3607516-01ML213
A20068-100ML213 100mg
A20068-50ML213 50mg
A20068-5ML213 5mg
A20068-25ML213 25mg
A20068-10ML213 10mg
A20068-2ML213 2mg
A20068-10mM-DML213 10mM * 1mL in DMSO

Popular Products