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WWQ-03-012

CAT: 0013-GTR19273975-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273975-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WWQ-03-012 is a selective inhibitor of deSUMOylating isopeptidase DESI2, with an IC50 of 47.3 μM. It induces ubiquitination-proteasome degradation of JAK2-V617F without significantly affecting wild-type JAK2. This compound can disrupt the JAK2-STAT3/5 signaling pathway, inhibit cell proliferation, and induce apoptosis. When used in combination with Ruxolitinib, WWQ-03-012 demonstrates a synergistic effect, enhancing cytotoxicity against JAK2 mutant cells. It is applicable in cancer research, specifically in studying myeloproliferative neoplasms.
CAS Number
3076807-15-0
Smiles
N (C (=O) [C@@H]1CN (C#N) CC1) C2=NC=3C (S2) =CC=C (C3) C=4C=C5C (=CC4) OCO5
Molecular Formula
C20H16N4O3S
Molecular Weight
392.43
Storage Conditions
-20°C
Notes
For research use only.

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