EGFR-IN-187

CAT: 0013-GTR19273930-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19273930-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

EGFR-IN-187 (Compound 4d) is a selective EGFR inhibitor with an IC50 of 25.41 μM. It exhibits inhibitory activity against PANC-1 and A549 cells with IC50 values of 0.067 μM and 2.29 μM, and selectivity indices (SI) of 1521 and 21, respectively. EGFR-IN-187 causes cancer cells to arrest in the S and G2/M phases and induces apoptosis and autophagy. It upregulates the expression of CCNE1, Bax, LC3B-II, and P27, while downregulating CCNA1 and Bcl-2 levels. EGFR-IN-187 is applicable for cancer research, including studies on lung cancer.

Storage Conditions

-20°C

Notes

For research use only.

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EGFR-IN-187

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