PMMB-187

• Target:

  STAT

• Related Pathways:

  Stem Cells|||JAK/STAT signaling

• Bioactivity:

  PMMB-187, a selective STAT3 inhibitor, exhibits an IC50 of 1.81 ?M in MDA-MB-231 cells. This compound induces apoptosis in MDA-MB-231 cells by inhibiting STAT3 transcriptional activity and nuclear translocation, reducing mitochondrial membrane potential, increasing reactive oxygen species (ROS) production, and upregulating the expression of apoptosis-related proteins. PMMB-187 is useful for research in the field of cancer.

• Smiles:

  O=C1C=2C(C(=O)C=C1[C@H](OC(CSC=3SC(CC4=CC=C(Br)C=C4)=NN3)=O)CC=C(C)C)=C(O)C=CC2O

• Molecular Formula:

  C27H23BrN2O6S2

• Molecular Weight:

  615.52

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2162952-37-4