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PMMB-187

CAT: 0931-T200126-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T200126-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2162952-37-4
Target
STAT
Related Pathways
Stem Cells|||JAK/STAT signaling
Bioactivity
PMMB-187, a selective STAT3 inhibitor, exhibits an IC50 of 1.81 ?M in MDA-MB-231 cells. This compound induces apoptosis in MDA-MB-231 cells by inhibiting STAT3 transcriptional activity and nuclear translocation, reducing mitochondrial membrane potential, increasing reactive oxygen species (ROS) production, and upregulating the expression of apoptosis-related proteins. PMMB-187 is useful for research in the field of cancer.
Smiles
O=C1C=2C(C(=O)C=C1[C@H](OC(CSC=3SC(CC4=CC=C(Br)C=C4)=NN3)=O)CC=C(C)C)=C(O)C=CC2O
Molecular Formula
C27H23BrN2O6S2
Molecular Weight
615.52
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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