COB-187

• Description :

  COB-187 is a potent, ATP-competitive and selective inhibitor of GSK-3β. COB-187 inhibits GSK-3 through a reversible and Cysteine (Cys) -199-dependent mechanism. COB-187 inhibits LPS induced cytokine production and SARS-CoV-2 spike protein-induced CXCL10 production[1].

• UNSPSC :

  12352005

• Target :

  GSK-3

• Type :

  Reference compound

• Related Pathways :

  PI3K/Akt/mTOR; Stem Cell/Wnt

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Cancer; Infection; Metabolic Disease; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/cob-187.html

• Purity :

  95.0

• Smiles :

  OC1(CSC(N1CC2=CC=NC=C2)=S)C3=CC=CC=C3

• Molecular Formula :

  C15H14N2OS2

• Molecular Weight :

  302.41

• References & Citations :

  [1]Mehrani R, et al. Capturing the Effects of Single Atom Substitutions on the Inhibition Efficiency of Glycogen Synthase Kinase-3β Inhibitors via Markov State Modeling and Experiments. J Chem Theory Comput. 2024 Jul 8.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  GSK-3β

• CAS Number :

  [1862177-86-3]