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COB-187

CAT: 0804-HY-162675-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-162675-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
COB-187 is a potent, ATP-competitive and selective inhibitor of GSK-3β. COB-187 inhibits GSK-3 through a reversible and Cysteine (Cys) -199-dependent mechanism. COB-187 inhibits LPS induced cytokine production and SARS-CoV-2 spike protein-induced CXCL10 production[1].
CAS Number
1862177-86-3
UNSPSC
12352005
Target
GSK-3
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Infection; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cob-187.html
Purity
95.0
Smiles
OC1(CSC(N1CC2=CC=NC=C2)=S)C3=CC=CC=C3
Molecular Formula
C15H14N2OS2
Molecular Weight
302.41
References & Citations
[1]Mehrani R, et al. Capturing the Effects of Single Atom Substitutions on the Inhibition Efficiency of Glycogen Synthase Kinase-3β Inhibitors via Markov State Modeling and Experiments. J Chem Theory Comput. 2024 Jul 8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3β

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